Certain Bioethical Aspects of Personal Dignity in Genomics

The paper deals with the constitutionalism and constitutionalization of certain provisions of genomics and bioethics at the present stage. The author analyzes constitutional domestic and foreign normative acts, the subject of which are relations in the field of genomics and the correlation of these relations with bioethics. The paper presents the opinions of Russian and foreign scientists regarding bioethics and related phenomena. The paper examines individual bioethical aspects, potential risks and threats, and searches for elements of the scientific concept of bioethical and somatic dignity of the individual in Russian legislation. The paper discusses the general issues of the legal regime of the human genome and the issues of genetic, genomic, biomedical research. The author raises the question of the balance of private and public interests as an optimal combination of personal interest and scientific ones. Having studied the legislation, the author speaks about the need to legally consolidate the definition of the concepts «genetic research with human participation» and «genomic research with human participation» at the federal level. The author expresses the opinion that the introduction of this conceptual apparatus into medical legislation would help to unify value-based legal approaches and models of legal regulation, and would also be the most important guarantee of the inviolability of human somatic dignity, eliminating unjustified risk and potential threats of subsequent biomedical research and experiments with human participation.

The author concludes: the categories of bioethical and somatic dignity require further disclosure in Russian legislation and state policy in the field of biomedicine.

1. Blinov AG, Lapunin MM. Predely vmeshatelstva ugolovnogo prava v sferu issledovaniya genoma cheloveka [The limits of criminal law interference in the field of human genome research]. Vestnik Permskogo universiteta. Yuridicheskie nauki [Perm University Herald. Juridical Sciences. Legal sciences]. 2020;4:804-831. (In Russ.).

2. Bondar NS. Konstitutsionnaya kategoriya dostoinstva lichnosti v tsennostnom izmerenii: teoriya i sudebnaya praktika [The constitutional category of personal dignity in the value dimension: theory and judicial practice]. Konstitutsionnoe i munitsipalnoe pravo [Constitutional and Municipal Law]. 2017;4:19-31. (In Russ.).

3. Vasiliev GV. Genomika [Genomics]. Vavilovskiy zhurnal genetiki i selektsii [Vavilov Journal of Genetics and Breeding]. 2014;18(1):158-165. (In Russ.).

4. Vlasova OV. Dostoinstvo cheloveka kak nravstvenno-pravovaya tsennost: obshcheteoreticheskoe issledovanie: dis. … d-ra yurid. nauk. [Human dignity as a moral and legal value: A general theoretical study. Dr. Sci. (Law) Dissertaion]. Khanty-Mansiysk; 2011. (In Russ.).

5. Kravets IA. Bioeticheskie vektory dostoinstva i kulturnogo raznoobraziya v konstitutsionnoy i mezhdunarodnoy bioyurisprudentsii: perspektivy konstitutsionalizatsii biobezopasnosti i dostizheniya bioeticheskogo blagopoluchiya [Bioethical vectors of dignity and cultural diversity in constitutional and international biojurisprudence: Prospects for constitutionalization of biosafety and achievement of bioethical well-being]. Konstitutsionnoe i munitsipalnoe pravo [Constitutional and Municipal Law]. 2023;1:7-17. (In Russ.). DOI: 10.18572/1812-3767-2023-1-7-17.

6. Kravets I. Konstitutsionnaya bioyurisprudentsiya i dostizhenie bioeticheskogo blagopoluchiya (ch. 1) [Constitutional bio-jurisprudence and achievement of bioethical well-being (Part 1)]. Sravnitelnoe konstitutsionnoe obozrenie [Comparative Constitutional Review]. 2022;2(147):16-42. (In Russ.).

7. Kravets IA. Homo Dignus v filosofskom i pravovom diskurse: chelovecheskoe dostoinstvo i filosofiya konstitutsionalizma [Homo Dignus in Philosophical and Legal Discourse: Human Dignity and the Philosophy of Constitutionalism]. Voprosy filosofii [Questions of philosophy]. 2020;2:26-37. (In Russ.). DOI: 10.21146/0042-8744-2020-2-26-37.

8. Kravets IA. Konstitutsionnoe pravo na bioeticheskoe blagopoluchie i dostoinstvo patsienta v sfere biomeditsiny: perspektivy normativnoy, zakonodatelnoy i sudebnoy konstitutsionalizatsii (otechestvennyy i mezhdunarodnyy aspekty [Constitutional right to bioethical well-being and dignity of the patient in the field of biomedicine: prospects of normative, legislative and judicial constitutionalization (domestic and international aspects)]. Vestnik Tomskogo gosudarstvennogo universiteta [Tomsk State University Journal]. 2022;483:261-272. (In Russ.). DOI: 10.17223/15617793/483/28.

9. Krylatova IYu. Perspektivy i ugrozy realizatsii konstitutsionnogo printsipa dostoinstva lichnosti v genomike [Prospects and threats to the implementation of the constitutional principle of the dignity of the individual in genomics]. Vestnik Surgutskogo gosudarstvennogo universiteta [Surgut State University Journal]. 2021;4:105-110. (In Russ.). DOI: 10.34822/2312-3419-2021-4-105-110.

10. Krylatova IYu. K voprosu o somaticheskom i bioeticheskom dostoinstve lichnosti [On the question of the somatic and bioethical dignity of the individual]. Konstitutsionnoe i munitsipalnoe pravo [Constitutional and Municipal Law]. 2022;12:22-25. (In Russ.). DOI: 10.18572/1812-3767-2022-12-22-25.

11. Ksenofontova DS. Pravovye osnovy gennoy terapii: v poiskakh balansa interesov [Gene Therapy Legal Framework: In Search of Balance of Interests]. Lex Russica. 2019;(6):143-152. (In Russ.).

12. Kuznetsov VV. Dostoinstvo kak nravstvennaya tsennost: dis. … kand. filos. nauk [Dignity as a moral value. Cand. Sci. (Phylosophy) Thesis]. St. Petersburg; 1998. (In Russ.).

13. Nevinskiy VV. Konstitutsiya Rossiyskoy Federatsii i dostoinstvo cheloveka (vospominanie o budushchem) [The Constitution of the Russian Federation and human Dignity (remembrance of the future)]. Konstitutsionnoe i munitsipalnoe pravo [Constitutional and Municipal Law]. 2013;11:48-54. (In Russ.).

14. Ozhegov SI. Slovar russkogo yazyka: 70 000 slov [Dictionary of the Russian language: 70,000 words]. 23rd ed., rev. Moscow; 1990. (In Russ.).

15. Paladev MA. Konstitutsionnoe pravo cheloveka na chest i dostoinstvo (osnovaniya, soderzhanie, zashchita): avtoref. dis. … kand. yurid. nauk [Constitutional human right to honor and dignity (grounds, content, protection). The author’s abstract of the Cand. Sci. (Law) Thesis]. Moscow; 2006. (In Russ.).

16. Pestrikova AA. Formirovanie etiko-pravovykh sposobov kontrolya za nauchnymi issledovaniyami v oblasti razvitiya i ispolzovaniya geneticheskikh tekhnologiy [The Formation of Ethical and Legal Methods of Control over Scientific Research in the Field of Development and Use of Genetic Technologies]. Aktual’nye problemy rossijskogo prava. 2020;10:157-167. (In Russ.).

17. Romanovsky GB. Genomika i prava cheloveka na vidovuyu neprikosnovennost [Genomics and human rights to species inviolability]. Grazhdanin i pravo [Citizen and law]. 2019;8:15-25. (In Russ.).

18. Romanovsky GB. Konstitutsionnaya pravosubektnost grazhdan v usloviyakh genomnoy meditsiny [Constitutional legal personality of citizens in the context of genomic medicine].Vestnik Permskogo universiteta. Yuridicheskie nauki [Perm University Herald. Juridical Sciences]. 2017; 37:260-271. (In Russ.). DOI: 10.17072/1995-4190-2017-37-260-271.

19. Romanovsky GB, Mokhov AA, Tarusina NN, et al. Biomeditsinskoe pravo v Rossii i za rubezhom [Biomedical law in Russia and abroad]. Moscow; 2021. (In Russ.).

20. Romanovsky GB. Genno-inzhenernaya deyatelnost i konstitutsionnye prava cheloveka [Genetic engineering and constitutional human rights]. Sovremennoe pravo [Contemporary law]. 2009;13:28-33. (In Russ.).

21. Romanovsky GB. Pravovoe regulirovanie geneticheskikh issledovaniy v Rossii i za rubezhom [Legal Regulation of Genetic Research in Russia and Abroad]. Lex Russica. 2016;(7):93-102. (In Russ.). DOI: 10.17803/1729-5920.2016.116.7.093-102.

22. Sergeev YuD, Mokhov AA, Yavorsky AN. Pilotnyy (eksperimentalnyy) pravovoy rezhim dlya otechestvennoy biomeditsinskoy nauki i praktiki [Pilot (experimental) legal regime for domestic biomedical science and practice]. Meditsinskoe pravo [Medical law]. 2019;4:3-6. (In Russ.).

23. Umnova IA, Stalnova AS. Konstitutsionnyy printsip uvazheniya dostoinstva cheloveka: obshchie podkhody v pravoponimanii i rossiyskaya konstitutsionnaya praktika [The constitutional principle of respect for human dignity: General approaches in legal understanding and Russian constitutional practice]. Konstitutsionnoe i munitsipalnoe pravo [Constitutional and Municipal Law]. 2016;10:15-20. (In Russ.).

24. Chernysheva YuA. Pravovye osnovy provedeniya biomeditsinskikh eksperimentalnykh issledovaniy s uchastiem cheloveka v RF [Legal basis for conducting biomedical experimental research with human participation in the Russian Federation]. Obshchestvo i pravo [Society and law]. 2011;4:304-306. (In Russ.).

25. Sharakshane SA. Dostoinstvo cheloveka: opyt filosofsko-antropologicheskogo osmysleniya: avtoref. dis. … kand. filos. nauk [The dignity of man: Experience of philosophical and anthropological comprehension. The Author’s Abstract of the Cand. Sci. (Law) Thesis]. Rostov n/D; 2007. (In Russ.).

26. Daryl ChJ. The Natural Law and Human Dignity: Reaffirming Ethical First Things. Liberty University Law Review. 2008;2(3).

27. Düwell M, Braarvig J, Brownsword J, Mieth D. The Cambridge Handbook of Human Dignity; 2014.

28. Dworkin R. Justice for Hedgehogs. Cambridge, MA; 2011.

29. Kateb G. Human Dignity. The Belknap Press of Harvard University Press Cambridge, Massachusetts, and London; 2011.

30. Waldron J. Dignity, Rank, and Rights. Oxford University press, 1995.